A new study carried out by the Diabetes Prevention Program (DPP) Research Group reveals that overweight people can reduce the risk of developing Type 2 diabetes by 58 percent by reducing their weight combined with an exercise program.
In the study performed by the US researchers and published in the National Diabetes Information Clearinghouse (NDIC) in October 2008, a total of 3,234 overweight people participated in a three-year diabetes prevention program. The participants were segregated into three groups: The first group, called the lifestyle intervention group, received intensive training in diet, physical activity, and behavior modification. By eating less fat and fewer calories and exercising for a total of 150 minutes a week, they aimed to lose 7 percent of their body weight and maintain that loss. The second group took the popular anti-diabetic drug Metformin (850mg twice a day), and the third receiving a placebo (an inert sugar-type pill labeled exactly like the Metformin drug). The Metformin and placebo groups also received information about diet and exercise but no intensive motivational counseling. At the beginning there was also a fourth group receiving the drug Troglitazone (Rezulin). This group was discontinued when it was discovered that Rezulin has the potential to cause serious liver damage.
After concluding the three-year prevention program, all participants had access to ongoing lifestyle coaching and were frequently monitored regarding their glucose blood levels over a period of ten years.
The group applying Metformin also showed a significant diabetes 2 risk reduction of 31 percent. Metformin was found to be most effective in men and women between 25 and 44 years and in those with a body mass index of 35 or higher (i.e. with at least 60 pounds overweight) and least effective in people over 45 years old.
Further analysis of the data also have added to the evidence that changes in diet and physical activity leading to weight loss not only reduce diabetes risk but also risk of cardiovascular diseases, including high blood pressure and metabolic syndrome. Participants in the lifestyle intervention group who did not have metabolic syndrome at the beginning of the study-about half of the participants-were less likely to develop it than those in the other groups.